Gastrointestinal Stromal Tumors: Update and Therapeutic Strategies
Keywords:
Gastrointestinal, Stromal, Tumors
Abstract
Abstract
Gastrointestinal Stromal Tumors (GISTs) represent a significant clinical challenge due to their resistance to conventional chemotherapy. This study aims to provide an update on the clinical, morphological, pathological, and therapeutic aspects of GISTs treated at our institution over an 11-year period. We highlight the efficacy of Imatinib as a targeted therapy and emphasize the importance of complete surgical resection. Additionally, we present a case of concomitant gastric adenocarcinoma and duodenal GIST, underscoring the need for comprehensive clinical evaluation in these cases.
References
1. Stamatakos M, Douzinas E,
Stefanaki C, Safioleas P, Polyzou E,
Levidou G, et al. Gastrointestinal
stromal tumor. World J Surg
Oncol. déc 2009;7(1):61.
2. Miettinen M, Lasota J.
Gastrointestinal stromal tumors.
Gastroenterol Clin.
2013;42(2):399‑415.
3. Katz SC, DeMatteo RP.
Gastrointestinal stromal tumors
and leiomyosarcomas. J Surg
Oncol. 15 mars 2008;97(4):350‑9.
4. Akahoshi K, Oya M, Koga T,
Shiratsuchi Y. Current clinical
management of gastrointestinal
stromal tumor. World J
Gastroenterol. 2018;24(26):2806.
5. Zalcberg JR, Verweij J, Casali PG, Le
Cesne A, Reichardt P, Blay JY, et al.
Outcome of patients with
advanced gastro-intestinal stromal
tumours crossing over to a daily
imatinib dose of 800 mg after
progression on 400 mg. Eur J
Cancer. 2005;41(12):1751‑7.
6. An W, Sun PB, Gao J, Jiang F, Liu F,
Chen J, et al. Endoscopic
submucosal dissection for gastric
gastrointestinal stromal tumors: a
retrospective cohort study. Surg
Endosc. nov 2017;31(11):4522‑31.
7. Zhang L, Smyrk TC, Young Jr WF,
Stratakis CA, Carney JA. Gastric
stromal tumors in Carney triad are
different clinically, pathologically,
and behaviorally from sporadic
gastric gastrointestinal stromal
tumors: findings in 104 cases. Am J
Surg Pathol. 2010;34(1):53.8. Nishimura J, Nakajima K, Omori T,
Takahashi T, Nishitani A, Ito T, et
al. Surgical strategy for gastric
gastrointestinal stromal tumors:
laparoscopic vs. open resection.
Surg Endosc. 24 mai
2007;21(6):875‑8.
9. Novitsky YW, Kercher KW, Sing RF,
Heniford BT. Long-term outcomes
of laparoscopic resection of gastric
gastrointestinal stromal tumors.
Ann Surg. 2006;243(6):738.
10. Joensuu H, Hohenberger P, Corless
CL. Gastrointestinal stromal
tumour. The Lancet.
2013;382(9896):973‑83.
Stefanaki C, Safioleas P, Polyzou E,
Levidou G, et al. Gastrointestinal
stromal tumor. World J Surg
Oncol. déc 2009;7(1):61.
2. Miettinen M, Lasota J.
Gastrointestinal stromal tumors.
Gastroenterol Clin.
2013;42(2):399‑415.
3. Katz SC, DeMatteo RP.
Gastrointestinal stromal tumors
and leiomyosarcomas. J Surg
Oncol. 15 mars 2008;97(4):350‑9.
4. Akahoshi K, Oya M, Koga T,
Shiratsuchi Y. Current clinical
management of gastrointestinal
stromal tumor. World J
Gastroenterol. 2018;24(26):2806.
5. Zalcberg JR, Verweij J, Casali PG, Le
Cesne A, Reichardt P, Blay JY, et al.
Outcome of patients with
advanced gastro-intestinal stromal
tumours crossing over to a daily
imatinib dose of 800 mg after
progression on 400 mg. Eur J
Cancer. 2005;41(12):1751‑7.
6. An W, Sun PB, Gao J, Jiang F, Liu F,
Chen J, et al. Endoscopic
submucosal dissection for gastric
gastrointestinal stromal tumors: a
retrospective cohort study. Surg
Endosc. nov 2017;31(11):4522‑31.
7. Zhang L, Smyrk TC, Young Jr WF,
Stratakis CA, Carney JA. Gastric
stromal tumors in Carney triad are
different clinically, pathologically,
and behaviorally from sporadic
gastric gastrointestinal stromal
tumors: findings in 104 cases. Am J
Surg Pathol. 2010;34(1):53.8. Nishimura J, Nakajima K, Omori T,
Takahashi T, Nishitani A, Ito T, et
al. Surgical strategy for gastric
gastrointestinal stromal tumors:
laparoscopic vs. open resection.
Surg Endosc. 24 mai
2007;21(6):875‑8.
9. Novitsky YW, Kercher KW, Sing RF,
Heniford BT. Long-term outcomes
of laparoscopic resection of gastric
gastrointestinal stromal tumors.
Ann Surg. 2006;243(6):738.
10. Joensuu H, Hohenberger P, Corless
CL. Gastrointestinal stromal
tumour. The Lancet.
2013;382(9896):973‑83.
Published
2023-09-29
Issue
Section
original article
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
