A Puzzle in the Spleen: A Case Report of Isolated Splenic Tuberculosis

  • W Benhami General Surgery Department, Djilali Rahmouni Public Hospital, Les Orangers, Algiers, Algeria,
  • H Badache General Surgery Department, Mohamed Lamine Debaghine University Hospital Center, Algiers, Algeria,
  • M Brahimi General Surgery Department, Djilali Rahmouni Public Hospital, Les Orangers, Algiers, Algeria,
  • H Guendouz General Surgery Department, Djilali Rahmouni Public Hospital, Les Orangers, Algiers, Algeria,
  • L Rahal General Surgery Department, Djilali Rahmouni Public Hospital, Les Orangers, Algiers, Algeria,
Keywords: Splenic tuberculosis, Cystic spleen, Extrapulmonary TB, Case report

Abstract

Abstract:

Background: Isolated splenic tuberculosis is a rare form of extrapulmonary tuberculosis, even in endemic regions. Its cystic presentation can mimic other splenic lesions such as hydatid cysts or abscesses, making diagnosis difficult.

Case Presentation: We present the case of a 53-year-old woman with six months of left upper quadrant pain. Clinical exam revealed a mild splenomegaly. Blood tests showed leukocytosis and elevated ESR. Imaging revealed multiple cystic splenic lesions, the largest measuring 70 × 35 mm, with peripheral enhancement. Chest X-ray and infectious workup were inconclusive. Due to diagnostic uncertainty, a laparoscopy followed by splenectomy was performed. Histopathology revealed caseating granulomas, confirming isolated splenic tuberculosis. The patient received anti-tuberculous treatment and remained well after two years of follow-up.

Conclusion:

This case highlights the diagnostic challenge of cystic splenic tuberculosis and underscores the importance of considering it in the differential diagnosis of atypical splenic lesions, especially in endemic settings.

References

1. Khaili NA, Jarti M, Haida MZ, et al. Splénomégalie multi-nodulaire révélatrice d'une tuberculose multifocale à localisation splénique et vertébrale : à propos d'un cas. Pan Afr Med J. 2021 Dec 16;40: 230. PubMed| Google Scholar

2. Jira M, Sekkach Y, Abouzahir A, et al. Tuberculose hépato-splénique. Presse Med. 2015 Feb;44(2): 258-9. PubMed
3. Rhazal F, Lahlou MK, Benamer S, et al. [Splénomégalie et pseudotumeur splénique d’origine tuberculeuse: à propos de six observations]. Ann Chir. 2004;129(8):410–414.
4. Arsène Gafourou Ouédraogo, Hamadé Zonon, Salamata Sanfo, et al. Multiple micro-abcès splénique révélant une tuberculose multifocale a localisation pulmonaire et splénique: à propos d´un cas. PAMJ Clinical Medicine. 2023;13:10. [doi: 10.11604/pamj-cm.2023.13.10.40920]
5. Tarantino L, Giorgio A, de Stefano G, et al. Disseminated mycobacterial infection in AIDS Patients : abdominal US features and value of fine-needle aspiration biopsy of lymph nodes and spleen. Abdom Imaging 2003;28:602–8.
6. Danon O, Mofredj A, Cava E, et al. Infarctus splenique révélant une tuberculose abdominale. Gastroen- terol Clin Biol 2000;24:240–1.

7. Chandra S, Srivasta DN, Gandhi D. Splenic tuberculosis: An unusual sonographic presentation. Int J Clin Pract 1999;53:318–9.
8. Wang Y, He G, Zhan W, Jiang H, Wu D, Wang D, et al. CT findings in splenic tuberculosis. J Belge Radiol. 1998;81:90–1.
Published
2025-07-01
Section
case report